The current experiment was conducted to evaluate the effects of feeding dried sweet orange peel (SOP) and lemon grass leaves (LGL) as feed additives on broiler growth performance, serum metabolites, and antioxidant status. A total of 192-day-old (Ross 308) broiler chickens were distributed randomly into 4 dietary treatments with 4 replicates per each treatment. The dietary treatments included a control diet without any feed additive (T1), a diet containing 0.8 % SOP (T2), a diet containing 0.8 % LGL (T3), and a diet containing combination of 0.4 % SOP + 0.4 % LGL (T4) was fed during the growth period from 22 to 42 days. Feed intake (FI), body weight gain (BWG), feed conversion ratio (FCR), carcass traits, serum components, and antioxidant status were measured. At the end of the experimental period, the results indicated that supplementation of SOP and LGL alone or in combination did not significantly (P > 0.05) affect BWG, FI, FCR, and carcass characteristics in broiler chickens. Serum total protein was increased significantly (P < 0.05) in T3 and T4 compared to the other treatments. Also, serum globulin increased significantly (P < 0.05) in the treated groups. Serum glucose, low density lipoprotein, triglyceride, and very low density lipoprotein decreased significantly (P < 0.05) in the treatment groups, while cholesterol and high-density lipoprotein decreased in T2 compared to the other groups. Significantly (P < 0.05) higher total antioxidant status was observed in T2 compared to the other treatments. In conclusion, these results indicate that SOP, LGL, and their combination may positively modify some serum components and the antioxidant status without any beneficial effect on growth performance and carcass traits in broiler chickens.

This study was carried out to evaluate the anti-inflammatory activity of flavonoid (Rutin 20 mg/kg) on each (carrageenan-induced paw edema) acute inflammation and (cotton pellet granuloma) chronic inflammation and, effect of rutin on some hematological, biochemical, and histopathological examination in guinea pigs induced by inflammation. A total of eighteen male guinea pigs were categorized into three groups, six pigs on all group. Group one as non-treated control, they given 5% carboxymethyl cellulose orally for seven days. Group two received single dose orally (20 mg/kg) Rutin for seven days. Group three received (10 mg/kg) Indomethacin orally for seven days. By injecting of 0.1 ml of carrageenan suspension in saline into the sub-planter superficies of the right hind paw, the acute inflammation (edema) was induced in all experiment guinea pigs one hour after compounds taken. Then estimated the volume of paw edema immediately after carrageenan injection through one, two, three and four hours by using a plethysmograph system (VGO Basile, Italy). The results indicated that, rutin (20 mg/kg body weight) showed significant lowered (P<0.05) in the carrageenan induced paw edema and cotton pellet induced granuloma model comparing with control and indomethacin groups. In addition, rutin (20 mg/kg) improved the hematological and biochemical profiles and able of maintain the biochemical varies related to inflammation. This was also supported by histopathological studies of liver sections. On conclusion, rutin possess anti-inflammatory activity. Thus, the rutin showed protective role against acute and chronic inflammation.