Summary. Aim: To evaluate the presence of the aggregated proteins in malignant and benign neoplasms for clarifying the role of impaired protein metabolism in the formation of the altered tissues. Object and Methods: The histological specimens prepared from the operative materials of 196 patients with different forms of malignant and benign neoplasms were stained with Congo red and Thioflavin T and studied under the light and polarization microscope. Results: The various forms of β-stacked protein aggregates (β-SPA) inclusions were detected in amyloids, keloid tissue, benign polyps, and several malignant tumors. Conclusion: The formation of non-functional protein aggregates proves the complex character of the impairment of protein metabolism resulting in local or systemic accumulation of secondary protein toxins results in β-SPA formation as the self-sustaining complex of parametabolic processes. The β-SPA formation is of considerable interest since their properties lead to the impairment of the normal physiological processes in adjacent tissues ensuring the chronic course of the pathology.
Современная неблагоприятная демографическая ситуация и состояние репродуктивного здоровья населения Российской Федерации создают одну из наиболее приоритетных медико-социальных проблем, требующих пристального внимания на государственном уровне, а в условиях реформирования здравоохранения проблема становится стратегически важной. В сложившихся социальноэкономических условиях наблюдается тенденция к «омоложению» контингента больных, росту числа острых гинекологических заболеваний, обусловливающих необходимость хирургического вмешательства и оказывающих в дальнейшем негативное влияние на репродуктивное здоровье женщин [1]. Почти 26% от общего числа пациенток гинекологического стационара нуждаются в экстренной оперативной помощи. Важным маркером демографической ситуации в стране и интегрирующим показателем репродуктивного здоровья является уровень материнской смертности. За последние 25 лет материнская смертность в мире снизилась
The morphological structure of the nasal polyps was studied. In adult patients, the vascular and glandular form of formations were isolated, in the childhood-vascular. Individual fibrosis polyps did not exist, the connective tissue, in one or another quantity is an integral structural component of all polyps. Eosinophilic tissue demonstrates the process's chronization and dystrophic changes, the eosinophils, as you know, promotes thrombus formation. Angiogenesis in the nasal polyps may be due to the use of therapeutic agents, for example, vasoconstrictors that affect the blood vessel tone, microcirculation, stimulating proliferative processes.
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