Acylation of the silyl esters of amino acids, specifically glycine, b-alanine, sarcosine, glycylglycine, and 6-aminopenicillanic acid, with 1-phenyl-3-oxo-2-methyl-1-cyclopentane carboxylic acid chloride yielded new analogs of the known antitumor antibiotic sarcomycin. The resulting compounds had high levels of antitumor activity.
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