The article is devoted to the analysis of the psychological status of medical students in conditions of exit from self-isolation, as well as the development of practical recommendations for psychologists of educational institutions. The research used the following techniques: technique for diagnosing the level of social frustration by L.I. Wasserman (as modified by V.V. Boyko), technique "Coping Strategy Indicator" by J. Amirkhan (adaptation by N.A. Sirota and V.M. Yaltonsky) and psychological stress scale -PSM-25 Lemyre-Tessier-Fillion. The method of processing empirical data was used Spearman's criterion for correlation analysis, the SPSS-21.0 application package and Microsoft Office Excel 2010. It was found that a significant proportion of students experience psychological stress and social frustration. The results of a psychological study of coping strategies of medical students in the conditions of coming out of self-isolation showed that they most often use strategies focused on solving problems and strategies focused on finding social support. High levels of psychological stress and social frustration affect coping strategies, i.e. the higher the level of stress and frustration, the more often students prefer the ineffective coping strategy "avoidance of problems". The obtained research data can be used in the work of practical psychologists of educational institutions, to draw up programs for the prevention and correction of emotional disorders and to increase the use of the coping strategies repertoire. Practical recommendations were offered for psychologists of educational institutions.