Objective. To develop a model of an integral index for complex assessment of varicose vein risk factors and estimate the influence of pregnancy on the occurrence of chronic vein diseases. Varicose veins (VV) and chronic venous insufficiency are one of the most widespread human diseases. This pathology in pregnancy has a clear picture, which is quite different from varicose veins in non-pregnant women. Materials and methods. Analysis of 1974 individual medical cards of pregnant women and puerperas of Maternity Hospital № 2 for the period of 20162019 was carried out. Out of them, 456 cards had a diagnosis of varicose veins of the lower limbs. The method was based on statistical analysis and integral indices. Results. The following risk diapasons were determined: low risk (favorable prognosis) 0.440.85; medium risk (favorable prognosis is possible) 0.861.28; high risk (unfavorable prognosis) 1.292.13. The quantity of pregnancies is not an unfavorable prognosis for women. Long statistical loads give unfavorable prognosis (1.341.43); family predisposition is an unfavorable prognosis (1.66); lifting loads depending on the quantity in grams (1000 favorable sign; 500010 000 unfavorable (1.211.870)); wearing tight clothes is not an unfavorable prognosis (0.88); hypodynamia medium risk (1.14); diet low and medium risk (0.750.95), obesity high risk (1.242.15). Conclusions. The obtained results permitted to detect the most significant risk factors for varicose veins during pregnancy. Medium and high-risk indices are the following: long statistical loads, family predisposition, lifting loads, hypodynamia, diet and obesity. They influence the development of varicose veins. There is a possibility to present a prospective prognosis for pregnant women and develop a complex of measures to decrease risks for chronic vein diseases taking into account individual features of patients.

Aim. Conduct a correlation analysis of the dependence of risk factors in the etiopathogenesis of chronic venous diseases. Materials and methods. On the basis of the GBUZ TO “Maternity Hospital № 2” of the city of Tyumen, an analysis of the patients’ data was carried out in the form of a clinical examination and questionnaires. The average age of the examined patients is 26 years. The survey involved 468 women in the period 2017-2019. Results. Among the surveyed patients, 52,4% had CVD. Pregnant women with CVD have subjective symptoms and objective symptoms. Dilated veins exist for less than 5 years in 86,5% of pregnant women, and in 13,5% – for more than 5 years. Varicose veins, with a predominant localization on the left lower limb, were found in 7,5%, on the right – in 11,1%, and on both legs – 81,5%. Conclusion. The use of a statistical indicator made it possible to calculate the dependence of the appearance of a disease in the presence of a certain risk factor – in this case, the correlation is direct, the relationship is close (0,94); as well as to evaluate the prognosis for pregnant women prospectively and create complexes of measures to prevent venous diseases, taking into account the individual characteristics of patients.

Introduction. Studies show that up to 8 % of pregnant women suffer from eating disorders. Such problems are found everywhere, most often women do not even realize that this may be related to problems. And for pregnant women, this issue is most relevant, since there is a risk of complications of the gestation period, after which it is necessary to prevent unfavorable variants of the course of pregnancy and childbirth.   Aim. To study the variants of eating disorders in pregnant women to assess the prognosis of pregnancy.   Materials and methods. We conducted a retrospective analysis of clinical case histories of pregnant women (n = 267), followed by a survey of women on the basis of the State Medical Institution “Maternity Hospital No. 2” in Tyumen. The study period is from 2019–2022. Two groups were identified for the analysis: 1st  – BMI of 18.5–24.9 kg/m2 : 2nd  – BMI of 25 kg/m2  or more. In order to determine the type of eating disorder, we used various versions of questionnaires.   Results. Of the total number of women surveyed, overweight (BMI) was determined in 149/267 (55.9 %, 2 group), in 118/267 (44.1 %, 1 group), BMI was within normal values. Risk factors were identified for the groups that could affect the course of the gestational process in the case of an identified eating disorder. When assessing comorbidity, gynecological diseases were detected, pathologies were significantly more common for group 2 62/149 (41.6 %). The dependence of the presence of a violation of any type of eating behavior and the risk of possible complications of pregnancy is not statistically significant.   Conclusions. To maximize the favorable course of pregnancy and reduce the risk of possible complications, it is necessary to prepare a plan of preventive measures, which will include nutrition planning with a detailed description of solutions for a certain type of eating disorder.

Aim. To identify predictors of the severe course of a new coronavirus infection. Materials and methods. A retrospective analysis of 120 clinical case histories of patients hospitalized in hospitals in Tyumen with a confirmed diagnosis of COVID-19 within one year (01.08.202001.08.2021) was carried out. The patients were divided into two groups: 1st with a favorable outcome (n=96), 2nd with an unfavorable (fatal) outcome (n=24). For a more complete analysis, scales for assessing the clinical condition of patients (SHOCK-COVID), severity assessment (NEWS2) were used. Information processing was carried out in the IBM.SPSS.Statistics-19 program (USA). Results. As a result of the study, the median age for the 1st group was significantly lower (58 years) than for patients of the 2nd group (69 years; p=0.029). A certain set of laboratory parameters for group 2 patients deviate significantly from the reference values (C-reactive protein CRP 7.6 [4.7; 15.2] mg/dl, D-dimer 1.89 [1.36; 5.3] mcg/ml, ferritin 605 [446.7; 792] ng/ml). When analyzed in groups, taking into account the main markers of the severity of the disease, using the V.Yu. Mareev CCAS-COVID (Clinical Condition Assessment Scale) scale, for the 1st group, the sum of the set of parameters was 6 [2; 7] points, which corresponds to the average severity of coronavirus infection, for the 2nd group 13 [9; 16] points severe course. For patients of the 2nd group, a significant increase in the indicators of an unfavorable prognosis was revealed in comparison with the 1st group. Conclusion. Thus, in this study, the level of CRP, ferritin, D-dimer, the percentage of lung tissue damage according to computed tomography results, SaO2 were significantly associated with an unfavorable prognosis.