The second harmonics generation of Nd-laser radiation (A = 1.06 microns) of the isomorphic family of crystals with yttrium-aluminium borate (YAB) structure -RAI, (BO,), (R = Y, Sm, Eu, Gd, Dy, Er, Ho, Tu) -investigated using the powdor method and the theoretical calculation of SHG-coefficients -are reported. The rcfraction indices (for I = 5481 A) and optical sign for all studied YAB-typo crystals are determined with the help of the immersion method. All studied crystals possess PM direction and oee-interaction. The SH-intensity is of KDP order of magnitude, with reasonable correlation of experimental and theoretical data. Theoretical analysis of the contributions of different ions t o the integral d;: magnitude has shown identical signs for all ion species in YAB structure type.Es wird uber die Erzeugung der zweiten Harmonisehen dcr Nd-Laser-Strahlung (1, = 1,06 pm) der isomorphen Kristallreihe mit Yttrium-Aluminium-Borat-Struktur -RAl,(BO,), (R = Y, Sm, Eu, Gd, Dy, Er, Ho, Tu) -die nach der Pulvermethode und mit Hilfe der theoretisohen Berechnung der Koeffizienten der 2. Harmonischen untersucht wurden, berichtet. It was reported by BALLMAN (1962a) on flux growing and preliminary investigations of some crystals with yttrium-aluminium borate (YAB) structure -RA13(B03)4 whereR = Y, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Yb. The structure of this isomorphic family is similar to the structure of the carbonate mineral huntite (CaMg,(CO,),). From the whole group more details are known for the YALJBO,),: space group R 32; cell parameters: a = 9.287 A, C = 7.256 A ; optically negative; no = 1.775, n, = 1.715; density 3.70 g c 1 r 3 ; Mohs hardness 7.5. All investigated crystals showed piezoelectric activity (BALL-MANN 1962b), and it was predicted by REZ the possibility of considerable optical nonlinearity. Now we report on the investigation of second harmonics generation (SHG) of Nd-laser radiation, fulfilled on powders and tiny crystals and theoretical calculation of SHG-coefficients.Tiny crystals of the studied family were grown in the flux in the temperature range 1150-850 "C with potassium trirnolybdate as solvent (LEONYUK et al.)

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Per the majority of authors, melanoma is the most common tumor diagnosed during pregnancy (31 % of all malignant neoplasms). In approximately 1/3 of women melanoma developed in child-bearing age is diagnosed during pregnancy or in the postpartum period. However, only some retrospective studies analyzed the effect of pregnancy on melanoma development, and conclusive data on development, progression and treatment of BRAF-mutant melanoma is lacking. In this subpopulation of patients, BRAF status supposedly can negatively affect disease outcome irrespective of treatment methods.The article presents a clinical case of recurrence of melanoma with the BRAF V600E mutation during pregnancy. The patient underwent lymph node dissection during pregnancy prolongation, after labor she received antitumor drug therapy with МЕК and ВRAF inhibitors. Melanoma recurrence during pregnancy did not worsen treatment outcomes for the mother and embryo.