This study considered possible immunological alterations that may be associated with keloid tumor formation. Laser immunonephelometry was used to quantitate circulating immune complexes and complement C3 and C4 among keloid formers. IgG complex level was significantly higher, while C3 and C4 were lower, than in the control population. The raised IgG was positively correlated with C4 (r = 0.15). When considered with reports of earlier workers, keloid genesis could result from genetic predisposition, environmental trigger, or localized and systemic immune complex formations. The relationship of these factors to a disequilibrium between fibroblast synthesis of collagen and turnover degradation still remains unclear.

A literature search reveals a lack of any previous attempt to implant foreign tissue into the epididymis. Instead, related studies have been carried out within the adjacent testis. Theoretically, there are peculiar immunobiological factors that can require separate consideration of the two adjacent sites. With this background, we designed the present work by removing the adjacent testis and subsequently used biochemical, histological, and electron microscopic methods to assess the fate of parathyroid allografts buried within the epididymis. Since the concept of immunological privilege is usually explained on the basis of the nature of lymphatic drainage, we also studied the pattern of lymphatic drainage at each allograft bed. In the analysis of our results, the animals were grouped according to the nature of lymph pattern from each transplant bed. We observed that prolonged survival of the tissue allograft occurred only when the lymphatic trunk draining the graft bed bypassed all retroperitoneal nodes and opened directly into the blood stream via the cisterna chyli. This anomalous survival is favoured by pretransplant splenectomy. These results demonstrate that the rat epididymis can sometimes be immunologically privileged.

No abstract

Obesity has become one of the major global problems, its emergence has created a lot of headaches griping the whole continent, (Africa) and yet on the rise, there are 120,000 death related to obesity in United States in 2010, according to WHO, Overweight and Obesity related conditions are the second leading of preventable death after tobacco smoking, It is also listed that obese children are more likely to stay obese into adulthood and more likely to die from any non communicable disease before the age of 55 than their thinner counterpart.