This study dealt with women of childbearing age with infertility against the background of the chronic inflammatory process in the stage of incomplete clinical remission, pronounced changes from pro, anti-inflammatory, regulatory cytokines, components and inhibitors of the complement system. Changes in the architectonics of proteins lead to serious functional disorders properties of peripheral blood erythrocytes in chronic kidney disease even in remission. The composition of blood plasma changes significantly during pathology, which in turn has a significant effect on cell morphology, lipidprotein interactions and the latter-related activity of its enzyme systems. There is a "tension" of the immune and metabolic statuses, which can serve to assess the severity of the disease, its prognosis, treatment effectiveness and preventive measures. "Women with infertility in chronic endometritis and infertility in kidney disease with infertility" was published by the European Society for Human Reproduction and Developmental Disorder (ESDD) in May 2013. The study found that despite the absence of clinical manifestations of inflammation, there was a destructive immune-inflammatory process that requires mandatory correction.

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ГБОУ ВПО «Курский государственный медицинский университет» Минздрава России, Курск, Россия Цель -установить характер иммунных изменений при хроническом эндометрите и провести коррекцию нарушений с применением низкоинтенсивного лазерного облучения крови наряду со стандартным лечением. Пациенты и методы. В исследование были включены 30 пациенток репродуктивного возраста с верифицированным диагнозом: хронический эндометрит в стадии неполной ремиссии. Все больные были разделены на 2 группы: контрольную (1-ю), в которой паци-ентки получали только медикаментозную терапию, и основную (2-ю), где лечение дополняли процедурами внутривенного лазерного облучения крови (ВЛОК) в течение 7 дней по 25 мин с использованием аппарата «Мулат» (длина волны 0,63 мкм, выходная мощность 2 мВт). Также была выделена группа сравнения (3-я), в которую вошли здоровые женщины. Уровень цитокинов, компонентов комплемента и иммуноглобулинов определяли в плазме крови и вагинально-цервикальном смыве методом твердофазного иммуноферментного анализа. Результаты. При использовании ВЛОК по сравнению с применени-ем только медикаментозной терапии установлена достоверная коррекция нарушенных показателей иммунного статуса на системном и местном уровнях (про-, противовоспалительные и регуляторные цитокины, компоненты и регуляторы систе-мы комплемента, иммуноглобулины). Вывод. Дополнение стандартной терапии хронического эндометрита курсом ВЛОК позволяет повысить ее эффективность и улучшить качество жизни пациенток. The objective of the present study was to elucidate the specific features of the immune disturbances in patients presenting with chronic endometritis and to correct them with the help of the application of low-intensity intravascular laser radiation of blood in the combination with the standard treatment. The patients and methods. The study included 30 women of the reproductive age with the verified diagnosis of chronic endometritis at the stage of partial remission. The patients were divided into two groups. The patients of group 1 (control) were treated by pharmacotherapy alone while those in the main group (group 2) were given standard therapy supplemented by intravascular laser irradiation of blood in the form of daily 25 min sessions during a 7 day period with the use of the «Mulatto» device having the output power of 2 MW at a wavelength of 0.63 microns. In addition, the third group of comparison was formed to which age-matched healthy women were recruited. The levels of cytokines, components of the complement, and immunoglobulins were determined in blood plasma, vaginal and cervical washouts using solid-phase enzyme immunoassay. Results. The more reliable correction of the immune disturbances was achieved with the use of low-intensive laser irradiation of blood in comparison with medicamental therapy alone as appears from the analysis of the indicators of the immune status at the systemic and local levels (anti-inflammatory and regulatory cytokines, components and regulators of the system of complement, immunoglobulins). Conclusion. Supple...

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