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Relevance of the study is to consider that in the post-industrial society the role of information and knowledge is so increased that they begin to occupy a decisive place in the production development.The purpose of the work is investigated interrelation of information and knowledge in the process of intellectual activity, which is a component of the production activity of the post-industrial production. The study task is to examine the role of information and knowledge in the formation of the new economy replacing the industrial one. In this paper used abstract-logical method historical method systemic and dialectical methods of analysis and synthesis. As a result of the research were justified "information" and "knowledge" as independent and interrelated categories; identifying peculiarities of knowledge that distinguish it from traditional production factors; studying intellectual activity as a component of the production activity.