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Purpose: to describe a clinical case of successful application of light-oxygen therapy (LOT) in a patient with plantar warts.Material and methods. The publication presents a clinical case of the successful outcome after light-oxygen therapy in the absorption spectrum of endogenous oxygen with its transfer to the singlet state in a patient with plantar warts. Russian-made diode laser «Super Seb», manufactured by LLC New Surgical Technologies (Moscow, Russia) with wavelength near 1265 nm, laser power 0–3 W was used as a source of laser light. Radiation power was from 2.1 to 2.7 W. Power density – from 0.86 to 1.86 W/cm2. Exposure dose – from 258 to 558 J/cm2. No anesthesia was required. The maximal surface heating temperature during the procedure was 41 °C. Temperature was controlled with non–contact infrared thermometer ELARI SmartCare model YC-E13 (manufactured by Zhengyang Yuncheng Medical Technology Co. Ltd., China) to eliminate thermal damage. Laser sessions were twice a week with 3–4 day intervals.Results. Complete clinical remission was achieved after 14 LOT sessions.Conclusions. Light-oxygen therapy is an effective and safe procedure for patients with plantar warts.