Klebsiella pneumoniae is one of common hospital-acquired bacteria causing nosocomial pneumonia, urinary tract infections, and intra-abdominal infections. The aim of this study is investigating the Modulation effect of Zinc Oxide nanoparticles (ZnO NPs) against multidrug resistant K. pneumonia which was isolated from Respiratory Tract Infections (RTIs). The results of isolation and characterization of bacterial specimens showed that 20.81% of RTIs were Klebsiella pneumoniae. The strongest isolate showed resistant for most usable antibiotics selected. Simultaneously, ZnO NPs were produced by an aqueous extract of Green Tea leaves as a reducing and stabilizer agent. The Ultraviolet-Visible (UV-Vis) spectrum was indicated a successful production of ZnO NPs at 383 nm. X-Ray Diffractometry (XRD) pattern showed peaks at 2θ positions matching to standards and indicating a formation of hexagonal (wurtzite) shape of ZnO NPs, with an average size of 22nm. Fourier Transform- Infrared (FT-IR) spectra of ZnO NPs revealed the participating of Green Tea biomolecules in the synthesis process. The minimum inhibitory concentration (MIC) of ZnO NPs against K. pneumoniae was 3.2 mg/mL. The results of using nanoparticles showed a morphological changing in K. pneumoniae colonies, and a modulation effect occurred against some antibiotic resistance of Klebsiella pneumoniae such as Gentamycin and Levofloxacin.

The purpose of the study was to determine the efficacy and safety ofintratesticular injection of ethanol or formalin as a novel method forchemosterilization of rabbits. Twenty rabbits, aged (6-8 months) and weighed(1.3-1.5) kg were used. They were randomly divided into two equal groups. Inthe first group, absolute ethanol and in the second group, formalin1% at a doseof 1ml/testis for each agent were injected under the effect of xylazine, byinsertion of the needle from the caudo-ventral aspect of the testis then pushed inthe center of the testis toward the cranio-dorsal pole of the testis. Orchidectomywas done at first and second months postinjection, samples from the testes andepididymis were taken for histopathological evaluation of testicular changes.Histopathological examination revealed atrophy of the seminiferous tubules,degeneration or vacuolation of sertoli cells and the leydig cells replaced byfibrous connective tissue. The of epididymis show narrowing of the epididymallumen. The severity and distribution of the lesions were more pronounced informalin group, although both agents had the ability to induce sterilization inrabbits.

The most common daily home oral care product with Toothpastes like an important oral hygiene habit for tooth care with many benefits to dental and gingival health. In fact, the components is always found in toothpastes are almost binding agents , gelling ,abrasive, humectant and surfactant, toothpaste components might cause bacterial resistance and damage fluoride as well as others problems in the presence or concentration of toothpastes components  may cause an expected lesions. This research has taken care to evaluate possible oral bacterial fluoride resistance or DNA degradation to oral epithelial cells exposed  for one kind of toothpaste has a high treating qualities considering in people uses.