The analysis of published clinical observations on the diagnosis and treatment of patients with Kimura's disease, which is a rather rare chronic inflammatory disease of human soft tissues of unknown etiology, is presented. The onset of Kimura's illness is hardly noticeable. The disease proceeds sluggishly, with a varied clinical picture, most often with the formation of single or multiple subcutaneous nodules or tubercles and swelling in the head and neck on one or both sides. Other localizations of lesions are also described: limbs, orbit, eyelids, palate, pharynx, armpit, chest, inguinal region. The affected areas gradually increase in size over many months or years. Other clinical manifestations of Kimura's disease are presented in the form of edema of the extraocular muscle, juvenile temporal arteritis, sleep apnea in cases of damage to the larynx, and life-threatening coronary artery spasm in children. There are reports of other rare systemic clinical signs of Kimura's disease in the form of pruritus, eczema and rash. The disease is often associated with regional lymphadenopathy and/or salivary gland involvement, eosinophilia, and an increase in serum immunoglobulin E from 800 to 35,000 IU/mL. The disease may be accompanied by kidney damage in the form of glomerulonephritis and nephrotic syndrome. Most reported cases of Kimura's disease occur in young Asian men in their 20s and 30s, sporadically the disease is diagnosed in Europeans, North Americans, Caucasians, and Africans. Diagnosis of Kimura's disease is often clinically difficult. It is primarily based on excisional biopsy of the lesion or regional lymph nodes, and the histopathological findings are consistent regardless of the location of the lesion. Morphologically, Kimura's disease is characterized by the presence in biopsy specimens of such histological features as reactive follicular hyperplasia with prominent follicles surrounded by fibrous tissue. Interfollicular infiltrates are rich in plasma cells and eosinophils, which form diffuse eosinophilic microabscesses associated with granulomatous inflammation. The vessels are numerous, with an increase in postcapillary venules. At the same time, the blood vessels remain thin-walled, with cuboidal endothelial cells. Treatment issues are highlighted, and differences between Kimura's disease and angiolymphoid hyperplasia with eosinophilia are presented.

Цель исследования -экспериментально-гистологическая оценка влияния местного применения окситоцина на заживление переломов нижней челюсти.Материал и методы. Материалом экспериментально-морфологического исследования служила нижняя челюсть в зоне перелома, скрепленного методом костного шва у 24 крыс-самцов линии Вистар массой 220-250 г. Препараты подвергались однотипной гистологической обработке на светооптическом уровне. Исследовали реакции с моноклональными антителами для идентификации экспрессии синтеза протеинов Кi67 , р56, bcl 2, caspasa 3.Результаты. Установлено, что динамика костно-раневого процесса при переломах нижней челюсти и оперативном закреплении отломков костным швом характеризуется фазностью. Светооптические и иммуноцитохимические исследования показали восстановление целостности поврежденной нижней челюсти после закрепления отломков костным швом посредством пролиферации клеток камбиального слоя надкостницы и малодифференцированных мезенхимальных стромальных костномозговых клеток. Полученные данные свидетельствуют об оптимизирующем воздействии на репаративный остеогенез включения в комплекс лечебных мероприятий окситоцина. При этом происходит коррекция элементарных репаративных процессов гистогенеза на уровне экспрессии про-и антиапоптотических генов клеток костной ткани (понижение апоптозной доминанты остеобластов по показателям экспрессии синтеза протеина р53, подавление ферментного каскада, реализация программированной гибели этих клеток по показателю экспрессии белка caspasa 3). Одновременно в регенерате возрастала активность антиапоптотического гена bcl-2 и гена Ki-67 у остеобластов и эндотелиоцитов, определяющих пролиферативный компонент репаративного остеогенеза.Ключевые слова: репаративный остеогенез, окситоцин, перелом нижней челюсти. Morphological and Immunohistochemical Characteristics of Experimental Mandibular Fractures Healing ProcessThe aim of the study is histological assessment of the effect of oxytocin local application on mandibular fractures healing.Material and methods. The investigated material was the lower jaw in the fracture zone, fastened by the bone suture method, of 24 Wistar male rats 220-250 g by mass. The preparations were subjected to the same histological processing and studied in light microscope. Reactions with monoclonal antibodies were performed to identify the expression of Ki67, p56, bcl 2, caspasa 3 proteins.Results. It was established that the dynamics of the bone-wound process in mandibular fractures and the operative fastening of fragments by bone suture is characterized by phase. Light-optical and immunocytochemical studies showed the restoration of the integrity of the damaged mandible after the fragments were fixed with bone suture through the proliferation of the cambial layer cells of the periosteum and low-differentiated mesenchymal stromal bone marrow cells. The data obtained indicate that the use of oxytocyte had an optimizing effect on reparative osteogenesis. When this occurs, the correction of elementary reparative processes of histogenesis at the ...

Using electron microscopic studies, the structural and functional reorganization of the neck skin and mucous membrane in patients with malignant tumors of the oral cavity at various stages of combined treatment is presented. Significant violations of tissue and cellular elements, their ultastructures, especially fibroblasts, intercellular substance of connective tissue and vessels of the microcirculatory bed were revealed, which exhausts the volume of compensatory and adaptive capabilities of tissue and cells included in the irradiation zone. The degree of structural and functional disorders in irradiated tissues is proportional to the amount of SOD.

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