Dr Mahmuda Siddiqua E-mail : mahmuda99@yahoo.com hepatitis, occurring in patients with no other known etiology. 5It is well established that HGV maintains a high and stable level of plasma viremia for many years, 6 which indicates it's efficient and active replication. Before the establishment of antibody detection methods, prevalence rates of HGV RNA in general population varied between less than 1 to 4% in different countries.7 With the development of new tests for detection of anti-HGV antibodies about 3 to 20 % of healthy people are found to have antibodies, indicating that the virus is more widely spread worldwide. In particular, rates of HGV seropositivity have ranged between 2-8% in Asia and North America, between 10-15 % in Europe and around 20% in South Africa and South America.