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The main directions of the search of biologically active compounds, pyrimi-dine derivatives are described.The synthesis of pyrimidines with anticancer, antimicrobial, antiviral activity is shown as the most frequent in recent years. The examples of compounds are given, which are already being used in medicine practice or may be good starting points for obtaining new drugs.

Synthesis of substituted benzoxazinylthieno[2,3 b]pyridines by the reaction of (3 cyanopyridin 2 ylthio)acetic acids or their amides with o aminophenyl(diphenyl)carbinolA general method for the synthesis of 3 amino 2 (4,4 diphenyl 4H 3,1 benzoxazin 2 yl)thieno[2,3 b]pyridines was proposed. The method involves reactions of (3 cyanopyridin 2 ylthio)acetic acids or their amides with o aminophenyl(diphenyl)carbinol in nitromethane in the presence of perchloric acid followed by neutralization of the resulting salts.Key words: (3 cyanopyridin 2 ylthio)acetic acid, (3 cyanopyridin 2 ylthio)acetamide, o aminophenyl(diphenyl)carbinol, 4,4 diphenyl 4H 3,1 benzoxazine, 3 amino 2 (4,4 diphe nyl 4H 3,1 benzoxazin 2 yl)thieno[2,3 b]pyridine.

Fused pyrimidine derivatives R 0515 Synthesis of Pentacyclic Systems Based on 3-Amino-2-(benzimidazolyl-2)thieno[2,3-b]pyridine. -(KAIGORODOVA, E. A.; VASILIN, V. K.; OSIPOVA, A. A.; LIPUNOV, M. M.; KRAPIVIN, G. D.; Izv.

Fused pyridine derivativesFused pyridine derivatives R 0450 3-(1-Pyrrolyl)thieno[2,3-b]pyridine -A New Conjugated Heterocyclic System -[synthesis by reaction of 3-aminothienopyridines (I) with 2,5-dimethoxytetrahydrofuran]. -(KAIGORODOVA, E. A.; OSIPOVA, A. A.; VASILIN, V. K.; KONYUSHKIN, L. D.; KRAPIVIN, G. D.; Chem. Heterocycl. Compd. (N. Y.) 39 (2003) 3, 400-401; Kuban State Technol. Univ., Krasnodar 350072, Russia; Eng.) -Staver 45-127