Current problems of Prinzmetal angina (vasospastic angina, variant angina) considers in this review. Attention is drawn to early diagnosis, which should be comprehensive, taking into account possible atypical courses and the development of complications. The important role of electrocardiographic monitoring (including using implantable recorders) is highlighted. It is emphasized that patients with cardiac arrhythmias, syncope are at high risk of developing sudden cardiac death. In this category of patients, it is recommended to timely determine the indications for implantation of a cardioverter - defibrillator. Authors consider the prospects of using new methods of treatment of angina pectoris.

Currently, due to the increase in life expectancy in the human population, the relevance of the problem of sarcopenia and chronic somatic pathology, including chronic heart failure (CHF), is increasing. At the same time, there are no clear recommendations for managing patients with a combination of CHF and sarcopenia. In addition, the impact of sarcopenia in combination with CHF on kidney filtration function remains poorly understood. The aim of the study was to evaluate the dynamics of muscle mass and strength, kidney filtration function in patients with sarcopenia and CHF in a longitudinal study involving 53 male patients with a mean age of 75.2 ± 7.3 years. The first (main) group (n = 24) consisted of patients with CHF and sarcopenia, while the second comparison group (n = 29) included patients with CHF without sarcopenia. The results showed that patients in the main group had a more pronounced decrease in muscle mass and strength over time, glomerular filtration rate (GFR), calculated using CKD-EPI formulas, based on cystatin C (CKD-EPICysC) and cystatin-creatinine (CKD-EPICysC+Cr) levels. In the comparison group, a more significant decrease in GFR, calculated using creatinine, was observed. It is emphasized that for more accurate determination of GFR in patients with CHF and accompanying sarcopenia, it is advisable to use the CKD-EPICysC formula. Future controlled randomized studies will determine the possibility of including this recommendation in appropriate protocols for managing elderly patients.

The article describes a clinical case of co-infection with COVID-19 and tropical malaria. Patient Z., 37 years old, arrived from the Central African Republic with a diagnosis of "New coronavirus infection COVID-19, confirmed (PCR RNA SARS-CoV-2 "+" from 27.01.22) mild form." During an objective examination, the subictericity of the sclera and skin integuments attracted attention, during thermometry - an increase in body temperature to 39.00C. Consciousness at the level of somnolence. Hemodynamics is unstable, episodes of arterial hypotension. Heart rate 96 per minute. Respiratory rate 24 in 1 minute, SpO2 95%, inspiratory dyspnea. According to a laboratory study, severe thrombocytopenia, pronounced signs of hepatic and renal insufficiency, hyperbilirubinemia, an increase in the concentration of C-reactive protein, procalcitonin were revealed. A differential diagnostic search was carried out between acute viral hepatitis and malaria. Blood microscopy revealed young trophozoites of Plasmodium falciparum (++++) using thick drop method. Antimalarial therapy was prescribed with Malacur, which was then replaced with parenteral Quinine followed by mefloquine. In parallel, extracorporeal detoxification operations were carried out. Against the background of adequate etiotropic therapy, complex intensive care measures, the patient's condition was stabilized, on the 40th day the patient was discharged from the hospital with the restoration of health.

Among respiratory infections, adenovirus infection (ADVI), in the presence of which there may be severe pneumonia that frequently results in a fatal outcome, occupies particular attention. ADVI in patients without immunodeficiency is usually mild and shows a limited extent of injury. At the same time the disease in immunocompromised individuals may be severe, presenting with viremia, evolving sepsis, and high death rates. The paper gives a characteristic example of severe ADVI and its fatal outcome.