Recently a new type of ANA, directed against the centromere region of chromosomes, has been described.3 These antibodies were found especially in patients with the CRST syndrome, a variant of scleroderma characterised by calcinosis, Raynaud's phenomenon, sclerodactyly, and telangiectasia.4 5 Since Raynaud's phenomenon is often an early manifestation of scleroderma and especially of the CRST
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.