Sepsis leads to metabolic acidosis through an excess production of lactate and end organ damage, tachypnea, and increased dead space. These processes decrease the end tidal CO 2 (EtCO2) pressure because they decrease PaCO 2 , decrease exhalation time, and reduce the available alveoli to excrete CO 2 , respectively. Therefore, EtCO2 might be a useful global measure of sepsis severity. In
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