Aim of this paper was to give an overview of fungal diseases prevailing on the most common vegetables grown in Novi Sad area. For investigation, lettuce and spinach grown in a greenhouse and in open garden were chosen. In greenhouse, optimal conditions for growing lettuce and spinach were maintained, which at the same time favor the development of fungal diseases. The vegetables grown in a protected suburban open garden were more problematic considering fungal diseases. In this paper, the prevention of fungal diseases was emphasized to avoid drastic chemical treatment or minimize its application. The adequate prevention in greenhouse is a good ecological measure