Good quality health information is certainly available on the Internet. However, it is not possible to predict with certainty which sites are of higher quality. We suggest clinicians should have a responsibility to educate their patients regarding the unregulated nature of medical information on the internet and proactively provide patients with educational resources and thus help them make smart and informed decisions.

Pulmonary sarcomatoid carcinoma (psc) is a rare subtype of non-small-cell lung carcinoma with a poor prognosis and poor response to chemotherapy and radiotherapy. A previous study reported that psc expresses high levels of PD-L1, suggesting the potential efficacy of immune checkpoint inhibitors in these tumours. We report 2 cases of patients with a lung sarcomatoid carcinoma. Both patients initially underwent curative lung resection, but developed early recurrent disease. Because PD-L1 was highly expressed in the tumour cells, we initiated therapy with nivolumab, which showed good efficacy, almost complete radiologic tumour remission, and a remarkable improvement in the condition of those patients. Immune checkpoint inhibitors targeting PD-1 might be a valuable therapy option for pscs.

SUMMARYFA 25-year-old female's laparoscopy revealed a soft, oval 4 cm lesion in anterior part of uterus between plica vesicouterina and the uterine cervix. Diagnosis of melanoma was made by histological and immunohistochemical method. Inferior median laparotomy with radical hysterectomy type II without ovarectomy was performed. The tumor was staged IVA of the International Federation of Gynecology and Obstetrics classification. The patient was B-RAF mutation negative. Treatment was initiated with chemotherapy.

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