e119 was 1-4 g/ml for pentamycin, 1-2 g/ml for nystatin, 0.5-1 g/ml for amphotericin B and 1-32 g/ml for fluconazole. Some strains of C. glabrata and S. cerevisiae, and most strains of C. krusei were categorized as susceptible-dose dependent or resistant to fluconazole, according to the CLSI document (MIC > 8 g/ml). At concentrations)4 g/ml, pentamycin inhibited completely the growth of 100% of strains of all species tested, including those strains less susceptible to fluconazole (MIC range: 16-32 g/ml). Conclusion: Pentamycin exhibited potent in-vitro fungicidal activity against the yeasts that are frequently isolated in recurrent forms of vaginal mycoses and mixed infections, like C.