Different 3,4-dihydrobenzo[2,3-d] pyrimidine derivatives were synthesized by the condensation of substituted 1, 3- cyclohexadienes and formamide, using inorganic solid supports under microwaves. Simple and commonly available compounds were used as starting materials in the reactions. The compounds were tested against different fungal and bacterial strains and found considerably effective. Key words: inorganic solid supports; microwave; benzopyrimidines; environmentally benign; antimicrobial DOI: 10.3126/njst.v11i0.4138Nepal Journal of Science and Technology 11 (2010) 153-158
A series of 1-(1,3,4-thiadiazolo)-2-thioxo-pyrimidines 4a-g are synthesized by the condensation of monosubsituted thioureas la-g, ethyl acetoacetate 2 and arylaldehyde 3 in dry media using microwave irradiation. The reactions are completed in very short time with high yield. The use of inorganic solid supports has been proved as an alternative mean of synthetic media.
Solid supported synthesis of some novel 3- (5'- substituted-2-furyl/thienyl) propen -2- oic acids has been carried out from malonic acid and 5- substituted furan/thiophene-2-carboxaldehydes under microwave irradiations in solvent free condition. The reaction completed in one step via condensation affording 88-96% of yield within 4-6 minutes. The reactions are accompanied with easy work-up, limited use of organic solvents and the use of inexpensive and hazard- free chemicals. DOI: http://dx.doi.org/10.3126/jncs.v29i0.9229Journal of Nepal Chemical SocietyVol. 29, 2012Page: 1-4Uploaded date : 12/3/2013
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.