In mining operations, including those in the Republic of Bashkortostan, the health of workers is not good, due to the impact of adverse occupational factors, as evidenced by the level of occupational morbidity in the industry. In this regard, the solution of issues of workers’ health protection is the most significant in occupational health. The working conditions of male workers of the main underground occupations of the enterprise producing copper-zinc ores have been studied. We have evaluated the dependence of the identified diseases on occupational factors and findings on occupational morbidity between 1997 and 2018. The results of the studies indicate a complex of adverse factors affecting the workers of underground occupations that determine the evels and structure of work-related morbidity, including occupational, the main forms of which are vibrational disease, sensorineural hearing loss, diseases of the musculoskeletal and respiratory systems. Diseases of the musculoskeletal system, upper respiratory tract and arterial hypertension with a risk level from «medium» to «very high» are regarded to be work-related. The greatest number of cases of occupational morbidity among the underground occupations has been established among drifters, fasteners, and mining technicians. Preventive measures aimed at modifying occupational factors and improving medical support for enterprise workers have been developed.

Introduction. The working population health is the basis of human capital, which is a factor in the country’s sustainable economic development. The conditions of occupational activity rank first in the structure of health factors of a working person. Materials and methods. The working conditions and the structure of the newly identified occupational morbidity at a metallurgical enterprise located in the territory of the Republic of Bashkortostan are analyzed based on statistical reporting documents on newly established occupational diseases for the period 2011-2019 and the hygienic characteristics of labour assessment presented by Rospotrebnadzor specialists with suspicion of an occupational aetiology of the diseases. Results. Over the past number of years, workers in manufacturing industries of the Republic of Bashkortostan (RB) have been diagnosed annually from 2.16 to 6.76 cases of occupational diseases per 10 thousand workers, which makes it possible to attribute these industries to a high level of occupational risk. Over the past decade, 117 cases (11 to 26 cases per year) of occupational diseases were detected at the enterprise for the first time. In the structure of nosological forms, musculoskeletal system diseases and connective tissue rank first. Limitations of the study. The limitation of this study is the lack of complete information about working conditions in the presented sanitary and hygienic characteristics. In recent years, there has been a decrease in registered occupational morbidity against the background of minor changes in working conditions. The identification of occupational diseases is often associated with the level of competence of employees of medical institutions who examine the relationship of the disease with the occupation and certain attitudes of the employee and employer. Conclusion. The working conditions of metallurgical workers are characterized by the impact of a complex of occupational factors, the leading of which is the intensity of the work process. The working conditions of this process are considered to be harmful Class 3 (3.3). Between 2011 and 2019, the link between the disease and occupational activity was established in 117 cases, mainly in workers (wire drawers, wire winders, repairmen, metal sorters) experiencing significant physical dynamic loads.

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The oil industry is a significant component of the industry of Bashkortostan. The complex of harmful factors for oil production workers includes industrial noise, vibration, exposure to harmful substances, the severity and intensity of work, unfavorable microclimate conditions. The researchers conditionally divide production factors of chemical nature into natural chemicals that are part of oil and associated gases (hydrocarbons, hydrogen sulfide, carbon monoxide, nitrogen oxide, mercaptans), and substances used to enhance oil recovery, preparation, transportation of oil and gas (reagents, acids, surfactants, methanol, welding aerosols). There is a role of changes in metabolic processes at the level of cells and subcellular structures in the development of pathological processes under the influence of harmful production factors in a number of studies. The study aims to substantiate the markers of early metabolic disorders in employees of an oil-producing enterprise. We conducted a study of metabolic processes in 340 oil production workers. The researchers represented the professional production groups by drillers (35.3%), operators of underground well repair (64.7%). The authors carried out characteristics of the factors of the working environment and the labor process of oil-producing industries in accordance with R 2.2.2006-05. The researchers also performed biochemical studies of the parameters of the lipid spectrum of blood serum, free radical processes and endogenous intoxication. The level of exposure to the average concentrations of the chemical factor at the workplaces of drillers and operators of underground well repair corresponds to classes 2-3.1. The influence of harmful production factors causes metabolic disorders in the body of oil production workers in the form of a violation of the lipid spectrum (an increase in total cholesterol, triglycerides), changes in the activity of cytolytic enzymes (GGT, AST, ALT), activation of lipid peroxidation processes, a decrease in catalase activity, an increase in the level of medium-molecular peptides in blood serum, which confirms the presence of endogenous intoxication syndrome in the examined workers. The impact of harmful production factors on the body of oil production workers causes metabolic disorders in the body and dictates the need for a complex of biochemical studies for the early diagnosis of prenosological processes and timely preventive measures.

The development of occupational allergic respiratory diseases in the Republic of Bashkortostan in 54% of cases is associated with exposure to aerosols of complex chemical composition exceeding MAC. Aggravating factors are unfavorable microcli-matic conditions in the workplace in combination with a chemical factor.