Nowadays foods are not purposed to only fulfill hunger and to supply vital nutrients for humans but, also to prohibit nutrition-related diseases and improve physical and mental well-being of the consumers. In this respect, functional foods play distinguished role. Therefore, the aim of this study was to examine the effect of addition of whey cheese and oat whole grain powder in biscuits and crackers by different formulae to produce low calorie biscuits and crackers, and to evaluate their effectiveness on weight gain and lipid profiles in rats fed on a high-fat diet. Feeding rats on different biscuits and crackers formulae recorded reduced body weight gain, adipocyte histological alteration. Feeding rats led to a significant reduction in the levels of LDL and total cholesterol and an improvement in the HDL levels.In conclusion, consumption of whey cheese and oat whole-grain in form of low calorie biscuits and crackers formula reduced the adipocytes histological changes, resulting in reduction of the body weight of the rats.