Background: Muscle injuries represent a great part of athletic injuries. The repairing of skeletal muscle after injury is highly influenced by its regenerative response that may be affected by thermotherapy. Aim: This research examined the consequence of heat therapy on muscle recovery after skeletal muscle injury in rats. Materials and Methods: Forty-five male adult albino rats were classified into three groups: control, cardiotoxin-injected without heat (nonheating group), and cardiotoxin-injected with heat (heating group). Muscle injury was caused by the injection of cardiotoxin intramuscularly into the tibialis anterior muscles. Heating treatment (40°C for 20 min) was started immediately after the injury. Subsequent observations were performed at day 1, 3, and 7 after injury, including histological imaging and vimentin immunostaining expression. Results: In the heating group, the regenerating myotubes, having two or more central nuclei, first looked at 3 days after muscle injury, while in the nonheating group, the regenerating fibers were first observed at 7 days after muscle injury. Immunohistochemically, the vimentin reactions were absent in control muscle fibers but were identified in regenerating muscle fiber of the heating group earlier than in the nonheating group. Conclusion: Starting of heat treatment immediately after muscle injury promoted the regeneration of muscle fibers.

Background: Tamoxifen is a drug that has been used extensively as a chemotherapeutic agent for breast cancer. It should be taken for a long period, from few weeks up to many years, so it can induce gynecological and nongynecological complications. Aim: Present study was conducted to clarify the histopathological effects of tamoxifen intake on the ovarian follicles of rats and evaluate the promising recovery after drug withdrawal. Materials and Methods: Adult female albino rats (n = 24) were randomly divided into four groups. Group I: Control rats without treatment. Group II: Rats received olive oil vehicle. Group III: Rats received 5 mg/kg daily of tamoxifen dissolved in olive oil by oral administration for 4 weeks. Group IV: Rats received tamoxifen as in Group III then will be kept for another 4 weeks without treatment for recovery. Then, the rats were anaesthetized and the ovaries were removed and prepared for histological assessment by light microscope. Results: The ovarian histological findings in the ovary of Group III revealed an increase in atretic ovarian follicles, appearance of cystic ovarian follicles, and cystic corpus luteum. The granulosa cells of ovarian follicles were disorganized with vacuolation of their cytoplasm, increased number of pyknotic nuclei, fragmented nuclei, and apoptotic bodies. After the withdrawal of drug, the ovarian tissue showed slight improvement with the appearance of some atretic follicles with degenerated oocyte and stromal hyperplasia. Conclusion: Based on the results, tamoxifen induced marked histological changes in the ovary. If tamoxifen is mandatory for the prevention of breast cancer, frequent gynecological examination should be carried out to detect any side effects.

Skin break out Vulgaris is perhaps the most widely recognized constant incendiary skin illnesses. It basically influences juvenile and some of the time proceeds into adulthood, however may introduce at whatever stage in life. For most patients, skin inflammation is described by the presence of comedones, papules, pustules and knobs. Lamentably, it might prompt perpetual distorting scars. It principally influences the face, neck, upper trunk and upper arms. Skin break out is a multifactorial sickness in which a few elements have been ensnared, including; hormonal impacts, follicular hyperkeratinization, and multiplication of P.acnes, provocative, natural and hereditary components. Responsive oxygen flavors and lipid peroxidation assume a job in the inception and movement of epithelial irritation in the pilosebaceous unit . In skin break out, sebum organization is changed. Lipid peroxidation of unsaturated fats creates both intracellular and extracellular ROS. The age of ROS can modify the consistency and arrangement of sebum. Isoprostanes are a gathering of prostaglandin-like mixes that are created by the response of free extremists with arachidonic corrosive , incorporating arachidonic esters in phospholipids. Creation of isoprostanes is very much recorded to increment in direct extent to the degree of oxidative pressure. Point : The point of current examination was to explore the relationship between serum level of 8-Isoprostane , and danger of AV among Egyptian patients. Technique: The current examination included 30 patients experiencing AV, notwithstanding 30 obviously solid people of coordinated age and sex as control gathering. All were researched for 8-Isoprostane level and thought about. 8-Isoprstane level was assessed utilizing monetarily accessible ELISA packs. End: From the aftereffects of present investigation, it is finished up 8-Isoprstane level is higher in skin break out vulgaris patients in corrospnding to the infection seriousness.