The preparation of three isomeric 1-tetralone hydrozones 4 and three isomeric 1-indanone hydrozones 5 possessing a single quaternary ammonium center is described. Several of the compounds possessed significant neuromuscular blocking activity, and two approached suxamethonium in potency. 1H NMR evidence obtained from a study of the N,N-dimethylhydrozones indicated that the hydrazones adopted an E configuration in solution.

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The p.m.r. characteristics of some 1 -amino-1 -(and 2-) methyl-3.3-diphenylpropane derivatives are reported and discussed. Unusual spectral features of the ketone derivatives (methadone and isornethadone) and of corresponding ketimines are related to probable conformations of these compounds as solutes in deuteriochloroform.

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