Platelet aggregation was assessed by the method of G. Born modified as described by Z.A. Gabbasov. Blood viscosity was measured using an AKR-2 rotating-type viscometer - rheological blood analyzer at six shear rates (10 s-1, 20 s-1, 50 s-1, 100 s-1, 200 s-1, and 300 s-1) simulating different intensities of the blood flow through the vessels. The model of arterial thrombosis induced by electrical current was constructed based on the method of G. Guglielmi et al (1991). Gliclazide was used in the studies of Limiglidol antiaggregant and antithrombotic properties and pentoxifylline in the studies of the influence of Limiglidol on rheological blood properties. It was shown that Limiglidol inhibited platelet aggregation and prolonged the time of thrombus formation. It proved to be superior to gliclazide in terms of these activities and reduced blood viscosity to a higher degree than pentoxifylline.