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Against the background of the use of a probiotic feed additive at a rate of 0.3 g/kg and 0.4 g/kg of fodder, in experimental calves, compared with the controlanalogs, there was a significant increase in the average daily weight gain on the 15th day of the experiment by 4.60-4.90%, on the 30th day - by 5.87 - 6.34%, on the 60th day - by 7.48 - 7.81%, in the blood of animals the number of red blood cells increased by 3.69 - 4.54%, leukocytes - by 1.48 - 1.75%, hemoglobin - by 6.39 - 7.59%, in blood serum the level of total protein - by 3.28 - 3.31% (P<0.05), albumin - by 2.08 - 2.69% (P<0.05), globulins - by 3.70 - 4.20% (P<0.05), gamma globulins - by 12.41 - 12.91 % (P<0.01). Introduction to the diet of calves of the specified probiotic feed additive promoted a slight increase of immunoglobulins A in blood serum in the experimental calves, in relation to the control analogues, in both experimental groups of animals by 5.00% (P<0.05), immunoglobulins M - by 4.43 - 5.64% (P<0.01), immunoglobulins G - by 5.69 - 5.90% (P<0.05), increasing the preservation of calves - by 3.22 - 3.69% (P<0.05).

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The article describes a method of preventing postpartum obstetric-gynecologic diseases and improving the reproductive function of cows by increasing the nonspecific resistance of the organism with the use of Prevention-N-B-S bio-preparation. For the first time the newly developed bio-preparation was injected to cows of Experimental Group 2 intramuscularly with a dose of 10 ml 35-30, 15-10 and 10-5 days before the expected calving date, while Dorogov’s antiseptic stimulant 2 fraction and Eleovit at the ratio of 1:9 were injected to the animals of Experimental Group 1 60 days before the estimated calving dates. It was established that the first estrus of Experimental Group 2 cows (28.8 ± 0.56 days) was 5.8 and 14.4 days earlier than that of the same-age cows of Experimental Group 1 (34.6 ± 0.93 days) and the Control Group (43.2 ± 1.64 days). The service period in Experimental Group 1 (64.6 ± 1.62 days) and Experimental Group 2 (57.8 ± 1.50 days) became shorter, comparing to the Control Group (89.2 ± 3.02 days). Use of bio-preparations in critical pregnancy periods of cows reduced the risks of subinvolution of uterus, endometritis and mastitis in the postpartum period and increased reproductive qualities of cows. The effect was most apparent when Prevention-N-B-S bio-preparation was used.

The feasibility of using Prevention-N-E, a newly developed and tested biological product, in comparison with the previously tested PS-6 preparation in the adaptive technology of keeping specialized beef cattle of imported breeding, had been scientifically substantiated and experimentally proved. Against the background of the use of drugs in animals of the 1st and 2nd experimental groups, the incidence of the digestive and respiratory organs decreased by 1.4 and 2.3 times, the recovery time reduced by 3.36 and 4.88 days, accordingly, compared with the control (P <0.05). By the end of the growing period, the animals of the 1st and 2nd experimental groups exceeded in live weight control subjects by 6.6 and 9.2 kg, rearing by 10.4 and 14.8 kg, and fattening by 14.2 and 22.2 kg respectively. In the cuts of the carcasses of bulls of the 1st and 2nd experimental groups, there was a bigger amount of the highest grade flesh: in spin-breast – by 1.0 and 1.0 kg, in the lumbar – by 0.2 and 0.4 kg, and in the hip – by 2.3 and 4.2 kg, rather than in the control.