The present study aimed to investigate the effect of spraying with IAA and GA3 and the interaction between them on improvement the growth, yield and some biochemical and physiological characteristics of wheat plant (Triticum durum serf Triticum aestivum) of two cultivars, Mohamed Ben Bachir (MBB) and Hedab (HD), were growing under different concentrations of sea water salinity ( 10%, 30% and 60%) and the comparison plant control was also used.The results showed decreased continuously in plant length and yield (as spikes and 100 wheat grain weight), with increasing the concentrations of salinity during the growth period, compared with untreated plants. The concentrations of salinity used, has negatively effect on number of leaves and proliferate (first generation) and the leaf area of plant. On contrast, proline content was increased with increasing the concentrations of salinity, this revealed that the plant exhibited resistant to salinity. The spraying with regulators of growth used in the present study (IAA and GA3), showed significant effect on plant, in the extent of reducing the hurt effect of salinity on the vegetative measurements and some physiological components of plant.