Computer-based art has recently played a pivotal role in the artistic process of producing digital versions of visual illustration. One of them is the digital painting trends which becomes a new phenomenon in art practice in Indonesia, a transformation between engineering, aesthetics, and culture. This study aims to develop the creative process in mixed media digital painting in the project of folklore visualization as a computer-based art practice. This study employed a research and development design which was carried out by following steps: (a) defining, (b) designing, (c) developing and (d) validating. Trial of development results (mixed media of digital painting) were carried out to art students in the visual arts department of the Faculty of Languages and Arts, Semarang State University who were working on art projects within the scope of folklore illustration. The results of the study showed that the development of mix media digital painting was conducted by using software that is applicable to combine graphic design of bitmap and vector graphics, namely Corel Draw X7 and Adobe Photoshop CS6. The combination between bitmap and vector graphics in folklore illustration project can improve shape variation and artistic effect in digital painting.