Morton's neuroma is a common injury of the forefoot that affects the third web space of the toes. The pain, localized to the forefoot and toes, may appear gradually but usually becomes significant and persistent. Often it occurs after walking and is relieved by removing the shoe and manipulating the forefoot. The management of this condition varies widely and includes conservative and surgical treatments. There is no general agreement on the optimal treatment for this pathology. The aim of this review was to collect and assess the scientific evidence reported in the literature supporting the different treatments in the management of Morton's neuroma, comparing the different outcomes of conservative and surgical treatments. A literature analysis was performed on the different managements in the search for the best scientific evidence on this topic.