Goal. Optimizing a differentiated approach to choice the method of internal biliary excretion for improvement the results of patients treatment with unresectable tumors of the hepatopancreatobiliary zone complicated by syndrome of obstructive jaundice. Material and methods. The results of surgical, endoscopic transpapillary, percutaneous transhepatic endobiliary interventions and their terminal application in 431 patients with inoperable tumors of the hepatopancreatobiliary zone complicated by obstructive jaundice syndrome are analyzed. Results. Were managed to perform palliative internal choleresis to all patients. Postoperative complications were noted in 9% of cases. Mortality rate was 7.66%. Long-term results were studied in 74.5% of patients in terms from 3 to 30 months. Conclusion. The proposed therapeutic algorithm determines the most effective use of surgical and minimally invasive variants of internal choleresis in patients with unresectable tumors of the hepatopancreatobiliary zone and allows avoiding the long-term complications characterised for bilioduodenal stenting.