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. Can. J. Chem. 59,641 (1981). The structures of the condensation products of isonicotinylhydrazine (isoniazid) with galactose, glucose, lactose, maltose, glycolaldehyde and glyceraldehyde were investigated by examination of their I3C nmr spectra, determined in D,O and DMSO-d, solution. Spectroscopic data and their interpretation are presented. Spectroscopic and chromatographic (hplc) evidence are combined to show that the products formed with the four sugars exist in solution predominantly as I-(1P-pyranosy1)-2-isonicotinylhydrazines, and to a lesser extent as the analogous la-pyranosyl anomers. 'The products formed with glycolaldehyde and glyceraldehyde are normal hydrazones.KEITH BAILEY et ANDREW G. BUTTERFIELD. Can. J. Chem. 59,641 (1981). Nous avons etudik les structures chimiques des produits de condensation entre I'isonicotinyl-hydrazine (isoniazide) et le galactose, le glucose, le maltose, le glyceraldehyde et le glycolaldehyde g r k e B leur spectres I3C rmn en solutions dans D,O et d,-DMSO. Les donnees spectroscopiques ainsi que leurs interpretations seront presentees. Ces donntes spectroscopiques renforcees avec des donnees chromatographiques (hplc) demontrent que les produits glucidiques se trouvent surtout dans la forme de 1-(lp-pyranosy1)-2-isonicotinyl hydrazine contenant une quantite moindre d'anomkres la-pyranosyl, tandis que les produits des deux aldehydes sont des hydrazones ordinaires. Introductionand hplc. Shortly after the completion of our work, Impurities in isonicotinylhydrazine (isoniazid, Take& (7) reported 13C nmr and other data for the isonicotinic acid hydrazide) drug formulations, INH-glucose product and some related substances formed by condensation of the drug with either lac-which Prompts us to repo* the

The high-speed liquid chromatographic behavior of 15 tetracyclines on anionand cation-exchange columns is described and illustrated by typical separations of a number of tetracycline derivatives on several systems, as well as by the resolution of tetracycline from its degradation products epi-, epianhydro-, and anhydrotetracycline. These serve as a basis for a rapid, convenient, and precise method for the direct detection of the tetracycline antibiotics and their degradation products.Tetracycline has been analyzed by titrimetric

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