Neurodegerative diseases NDDs, such as Alzheimer’s and Parkinson’s diseases influence the brain tissues and cells that led to perpetual damage, reduce the quality of life and life-threating, although considerable advances in conception the mechanisms of these diseases and their pathogenesis. Thus, developing effective treatments against neurodegenerative disorders still challenging. In this regard, imidazole derivatives have showed a potential to be multi target-directed agent that has multifunctional biological activities to restrict NDDs. Imidazole is a heterocyclic compound with structural features enable different biological activities based on the substituted. This review discusses the roles of different imidazole derivatives to be candidate as a treatment of NDDs. Modification of imidazole moiety has been recognized so as favorable multi target to treat NDDs. Herein, we suggest that imidazole can be modified properly to increase its potential to be applied for pre-clinical and clinical studying of NDDs treatment.