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THE ROYAL MEDICAL BENEVOLENT COLLEGE. method of analysis that ho has adopted. If Dr. Rake has further opportunities of prosecuting his research I would suggest that he might adopt a method by which his results can be more accurately compared with those obtained from normal blood which he quotes. The particular points to which his attention shouki be directed are : (1) Soaking fibrin in water for some hours is not sufficient to free it from corpuscles (it is better to place it under a running stream of water, kneading ib frequently in order that all parts of the coagulum are exposed to its action) ; (2) fibrin dried on blotting-paper cannot ba accurately spoken of as dried fibrin-dried fibrin is lib.,in which has been exposed in a hot-air oven at 110° C. for some hours until it loses no further weight from evaporation of water ; (3) after this the mineral admixture has still to be deducted, this being ascertained by weighing the ash left after ignition. I remain, Sirs, yours truly, King's College, Jan. 9th, 1892.

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