Objective To compare the efficacy of dehydrated and cryopreserved heterologous corneal grafts in the management of full‐thickness corneal defects in cats and dogs. Animals Studied Sixty‐five cats (81 eyes) and 42 dogs (51 eyes) with full‐thickness corneal defects of different origin. Materials and Methods This prospective randomized trial included 132 animal eyes (81 feline and 51 canine) with different full‐thickness corneal defects. Penetrating keratoplasty with cryopreserved and dehydrated corneal grafts was performed in 57 and 75 eyes, respectively. Follow‐up lasted for 6 months. Results Optically clear cornea with mild scarring was achieved in 40.4% of cases (23/57 eyes) after cryopreserved and in 42.7% of cases (32/75 eyes) after dehydrated corneal grafting. Moderate scarring after cryopreserved and dehydrated corneal grafting was observed in 35.1% of cases (20/57 eyes) and 37.3% of cases (28/75 eyes), respectively. Severe scarring and corneal opacities with severe vision loss after cryopreserved and dehydrated corneal grafting developed in 22.8% of cases (13/57 eyes) and 18.7% of cases (14/75 eyes), respectively. In two groups of animals combined, the affected eyes were salvaged and visual function improvement of varying degree was achieved in 78.0% of cases (103/132 eyes). Transplant rejection warranted enucleation in 1.75% of cases (1/57 eyes) and 1.3% of cases (1/75 eyes) after cryopreserved and dehydrated corneal grafting, respectively. Conclusions No statistically significant differences in clinical outcomes of penetrating keratoplasty with cryopreserved and dehydrated corneal grafts were observed. Dehydrated cornea may be considered a viable alternative to cryopreserved grafts for the management of full‐thickness corneal defects.

The treatment of pathologies of posterior segment of eye, such as chorioretinitis, uveitis, various neuroretinopathies, vitreous diseases, intraocular hemorrhage, is a rather serious problem due to the difficulties of the adequate delivery of preparations into area of pathological process. One of the most effective ways to deliver drugs to eye tissue in posterior segment are intravitreal injections. The introduction of drugs is carried out directly into vitreous body through a puncture of sclera. This article presents the indications for intravitreal injections, a detailed description of properties of numerous therapeutic agents that can be delivered through intravitreal injections, potential complications of this technique and recommendations for prevention of side effects.

The lens dislocation (ectopia) is a partial or complete lens displacment from the normal anatomical position to the anterior chamber of an eye or into the vitreous body due to a violation of the integrity of the Zinn ligaments that hold the lens in a normal position. There are two different methods for dislocated lenses removing ― the «open sky» surgery technique or the ultrasonic phacoemulsification. According to results and clinical analysis of the lens dislocation surgery in small pets we have identified that using the «open sky» surgery is the optimal method for lens dislocation surgery in the anterior chamber in aged cats and dogs or pets with severe somatic pathology. Our technique of surgery with performing diamond microsurgery is more efficient and perfect, requires much less time than phacoemulsification. It optimizes the stages of the operation, minimizes complications and significantly improves the results of operations.

The article reflects the influence of corneal collagen crosslinking on changes in the morphofunctional signs of the corneal stroma. Data on changes in the anterior layers of the stroma, which are expressed by a compact packing of fibers without signs of even minimal edema, as well as a demarcation line separating the area of impact from the indifferent zone, are scientifically substantiated. Clinical observation of cats and dogs after keratoplasty using a crosslinking modified cornea showed the most favorable course of the postoperative period which was expressed in an increase in the resistance of the collagen matrix of the donor tissue to collagenases which is especially important when using large and giant transplants.

The article presents the morphological substantiation of the feasibility of using corneal collagen crosslinking, as well as comparative characteristics of standard therapeutic animal treatment with septic cornea ulcers and modified crosslinking. Methods of ophthalmological examination of small pets after modified crosslinking revealed the most favorable (in 91.2% of cases) recovery in comparison with the standard therapeutic technique, which is confirmed by keratomalacia inhibition, acceleration of corneal epithelization rate and reduction (by 40%) of rehabilitation period of the animal.