Subject of our research is dental examination and identification of the features of the dental status in women with pregnancy complicated by gestosis. There is no doubt that pregnancy is a critical period for woman’s dental health. Objectives. Determine the dental status in women with pregnancy complicated by gestosis. Methods. As part of the study of the dental status of women with pregnancy complicated by gestosis, we conducted a clinical examination of the oral cavity in 127 women. The depth of the vestibule, the level of attachment of the bridles, the state of the bite, the indices of the KPU, IK, PMA, IZN were determined. Results. Our data indicate that the complication of the course of the third trimester of pregnancy with gestosis in women is accompanied by a deterioration in periodontal status, oral hygiene, and a 100% prevalence of gingivitis. Conclusions. The results of the study made it possible to obtain clinical and dental data characterizing the effect of pregnancy complicated by preeclampsia in women in the third trimester on the course of gingivitis, which is the basis for the development of methods for optimizing and increasing the effectiveness of therapeutic and prophylactic measures in this group of patients.

Preterm birth is one of the main causes of perinatal morbidity and mortality, which does not tend to decrease in rate. The risk of death in premature babies is 2535 times higher than that of full-term babies, and stillbirths are registered 813 times more often than in timely delivery. To date, there are no effective ways to prevent preterm birth. Therefore, the timeliness of therapy, which largely determines the outcome of pregnancy in general, depends on the effectiveness of assessing the likelihood of their development. At the International Federation of Gynecology and Obstetrics (FIGO) Congress (2018), preterm birth is identified as a problem that has not yet been solved at the current stage of science and technology development. The result of the unsolved problems is a situation wherein the modern world over the past 60 years there has been no decrease in the premature birth rate, which is 9.5% of births and annually ends with the birth of 15,000,000 premature babies. The study aimed to research modern methods of diagnosis and prediction of spontaneous preterm birth. An analytical method was used in the study: a detailed systematic analysis of modern domestic and foreign literature on the diagnosis and prognosis of preterm birth. We used eLibrary, Scopus, PubMed, MEDLINE, ScienceDirect, Cochrane Library bibliographic databases (until August 2020). The article deals with the diagnosis and prediction of preterm birth probability, which will optimize the management of patients from the risk group and, in the future, will reduce the rate of perinatal morbidity and mortality of premature babies. Despite a significant number of researches devoted to the study of possibilities for diagnosing and predicting spontaneous preterm birth, currently, there are no methods with absolute diagnostic value. Most -existing studies indicate that when assessing the probability of preterm birth, a comprehensive approach should be preferred taking into account the results of several main and additional methods.

Background. Ovarian hyperstimulation syndrome is a fatal complication of unknown etiology. In connection with the increase in the frequency of this complication, it is necessary to identify prognostically significant markers to discover the risk of its development. Aim. To analyze the frequency of ovarian hyperstimulation syndrome and search for the association of genes for differential growth factor 9, luteinizing hormone/horiogonadotropin receptor, and follicle-stimulating hormone receptor with different responses to ovulation stimulation. Material and methods. A retrospective single-center cohort study of the frequency and clinical parameters of early ovarian hyperstimulation syndrome was carried out in 147 patients, the average age was 36.5 [3338] years, who underwent an in vitro fertilization program in the period 20062021 in the Department of Assisted Reproductive Technologies of the Republican Medical Genetic Center in Ufa. The study of polymorphic loci of the genes for differential growth factor 9, luteinizing hormone/choriogonadotropin receptor, and follicle-stimulating hormone receptor was performed using TaqMan technology and real-time polymerase chain reaction. Deoxyribonucleic acid was isolated from peripheral blood samples. Statistical analysis was performed using the KruskalWallis criteria, median test, Pearson's 2 test, using the Statistica 12 software package. Results. 7577 procedures of assisted reproductive technologies were performed. 147 (2.3%) cases of ovarian hyperstimulation syndrome were registered, 53 (0.8%) cases of moderate and severe degree, 84 (1.3%) cases of mild degree. The *CT genotype of the rs254286 polymorphic locus of the differential growth factor 9 gene was associated with a poor ovarian response 15 (0.75); (2=4.00; p=0.02; odds ratio 3.4; 95% confidence interval 1.1310.27). The distribution of allele and genotype frequencies of the other studied genes did not differ statistically significantly in all the studied groups. Conclusion. The frequency of ovarian hyperstimulation syndrome in the Republic of Bashkortostan was 2.3%; the *CT genotype of the rs254286 polymorphic locus of the differential growth factor 9 gene, as well as the level of anti-Mllerian hormone, can serve as markers of a poor response and ovarian hyperstimulation to ovulation stimulation.

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BACKGROUND: According to WHO (2015), abortion complications account for 8% of maternal deaths. These statistics have prompted the search for new ways to safely terminate early pregnancy. In 2010, at the World Congress of Obstetricians and Gynecologists in Lisbon, medical abortion was called a world revolution. Due to the introduction of medical abortion, maternal mortality after abortion decreased by 20,000 persons in 2012. Medical abortion using prostaglandin preparations, which can be used to solve this problem, is safer than surgical abortion, since curettage of the uterine cavity can cause inflammation, mechanical trauma, and infertility. In the Russian Federation, a prostaglandin preparation (misoprostol 200 mcg) has been certified for medical termination of pregnancy. However, this drug is expensive, as it is manufactured through complex chemical synthesis. At the Ufa Institute of Chemistry, Russian Academy of Sciences (UIC, RAS), due to a directed search for uterotonics among 11-deoxyprostaglandins of the E- and F-groups, a promising analog of prostaglandin E1 with a higher uterotonic activity than misoprostol was revealed. The agent is 11-deoxymisoprostol (11-DMP), which is several times cheaper and more accessible for synthesis. AIM: This study aimed to compare the pharmacological properties of misoprostol and 11-deoxymisoprostol. MATERIALS AND METHODS: The experiments were performed on non-linear white rats weighing 190210 g. The animals were fed with a standard diet for the entire experimental period. Animals were monitored and assessed on a daily basis. Animals were divided into six experimental groups, using their body weight as the main criterion for randomization (deviation of body weight values within the group was no more than 10%), with 20 animals in each experimental group. The drug was administered intragastrically at a dose of 10 mg/kg. To assess the immunotoxic properties, we studied the indicators of nonspecific and specific humoral immunity and cellular immunity in rats and assessed its effect on the mass of lymphoid organs and their cellularity. The allergenic properties of 11-DMP were evaluated using the methods of anaphylactic shock, indirect reaction of mast cell degranulation, reaction of immune complexes, and conjunctival test. RESULTS: After administration of 11-DMP, a decrease in the rate of weight gain, changes in behavior, and death of animals were not observed in any of the studied groups of males or females. The fertility index did not differ significantly in all experimental groups. The average number of fetuses per female, the sex ratio of rat pups, and the death rate of newborn rat pups did not change in the broods of all experimental groups. The study of the allergenic effect of the drug revealed that 11-DMP does not have allergenic properties, as shown by the reactions of mast cell degranulation, immune complexes, and the conjunctival test. CONCLUSIONS: When studying the pharmacological properties, it was revealed that 11-DMP compared with misoprostol has higher uterotonic properties; the therapeutic margin is 2 times greater, the toxicity is 2 times lower, and it is more stable and has a more accessible route of chemical synthesis.