Study Objective: To evaluate the impact of multifollicular ovarian stimulation in in vitro fertilisation (IVF) programmes on hemostasis. Study Design: perspective comparative study. Materials and Methods. The study included 68 patients divided into two groups: study group (n = 36) — infertile patients; control group (n = 32) — healthy non-pregnant women of reproductive age. The protocol with gonadotrophin releasing hormone antagonists was used for ovulation stimulation. Hemostasis system in study patients was evaluated in 2 weeks after embryos were transferred to uterus; in control group — on day 20–22 of menstrual period. For the study group, we evaluated clotting test parameters of hemostasis system, D-dimers (D-d) and fibrin monomer (FM). Study Results. We have not found statistically significant differences between hemostasis screening results of study groups. We have identified increase in pro-coagulatory properties of blood in the study group patients: increase in FM and D-d (р < 0.0001 in both cases). There is an association between study parameters and pregnancy (p < 0.001) and no association with obesity, age and infertility. Conclusion. In IVF programme, FM and D-d levels rise, evidencing hypercoagulation development. An increase in FM levels was even more significant and can be used as an early and specific fibrogenesis marker. Keywords: assisted reproductive technologies, fibrin monomer, D-dimer, hypercoagulation, venous thromboembolic events.
Учебное пособиеФедеральное государственное бюджетное образовательное учреждение высшего образования «Первый Санкт-Петербургский государственный медицинский университет им. И.П. Павлова» Министерства здравоохранения Российской Федерации Федеральное государственное бюджетное образовательное учреждение «Национальный медицинский исследовательский центр им. В.А. Алмазова» Министерства здравоохранения Российской Федерации ФГБОУ ВО «ПСПбГМУ им. акад. И. П. Павлова» Минздрава России Кафедра акушерства, гинекологии и репродуктологии, кафедра акушерства, гинекологии и неонатологии ФГБУ «НМИЦ им. В. А. Алмазова» Минздрава России Кафедра акушерства и гинекологии, кафедра анестезиологии и реаниматологии, кафедра внутренних болезней, кафедра лучевых методов диагностики, кафедра кардиологии, кафедра эндокринологии ВНЕБОЛЬНИЧНЫЕ ПНЕВМОНИИ У БЕРЕМЕННЫХ: дифференциальная диагностика, особенности лечения, акушерская тактика в условиях пандемии новой коронавирусной инфекции COVID-19 МКБ-10 (J13-J16 и J18; U07.1, U07.2) Учебное пособие
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