The present research topic entitled “Assessment of Physico-Chemical parameters of soil from different blocks of Prakasam district, Andhra Pradesh" was carried out at the Naini Agricultural Institute, Sam Higginbottom University of Agriculture Technology and Sciences, Prayagraj. Department of Soil Science and Agricultural Chemistry (U.P.). During the year 2021-2022. In the present study Physico-Chemical analysis of soil in three blocks from nine in each hamlet, a single farmer’s land was chosen for sampling, and samples were taken at three depths: 0-15 cm, 15-30 cm, and 30-45 cm, of a total 27 samples collected and analysed using conventional laboratory techniques. Bulk Density ranged 1.29 -1.46 Mg m-3, Particle Density ranged 2.42-2.55 Mg m-3, Percent of Pore Space varied 42.68-48.00%, Water Holding Capacity varied 40.00-46.50%, and Specific Gravity varied 2.27-2.66. The pH ranged 6.42-9.04, EC ranged 0.16-0.35 dS m-1, Organic Carbon varied 0.26-0.53% and Available Nitrogen varied from low to medium 225-321 kg ha-1 Available Phosphorus varied from medium to high range 12.03-23.69 kg ha-1. And Potassium was found to be medium range 135.62-234.65 kg ha⁻1. It suggests that still improvement can be done by improving cropping pattern.