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The results of this general practice study suggest that acetylcysteine (Fabrol) administered orally for 2 months to patients with chronic bronchitis effectively changes the viscosity and character of sputum with resultant ease of expectoration and cough severity. There was a notable improvement in associated abnormal physical signs such as the presence of rhonchi, crepitations and symptoms including dyspnoea at rest. Tolerability was good, with 81% of patients experiencing no side-effects.

16. Statistical Distributions: A Handbook for Students and Practitioners. By N. A. J. Hastings and J. B. Peacock. London, Butterworths, 1974. xiii, 130 p. 834″. £1·80.