Summary. The aim of the study was to improve the results of treatment of patients with diabetic foot syndrome by applying a complex method of VAC-associated therapy. After 5 days of this treatment we enhanced the local blood flow of wounds from 27-31 to 52-54 mm Hg. (p<0.01), while in the comparison group the blood flow was 29-34 mm Hg, granulation tissue in the wound developed on average 4.93±0.64 days, which was significantly faster than in the control – 9,42±0.81 (p<0,05). Contamination of the wound of the main group before treatment was 8,4±0.14 Lg CFU/g of tissue, for 5 days – 2,8±0.21 Lg CFU/g of tissue, and the regenerative-inflammatory type of cytograms dominated. For 10 days the pathological microflora in the wound was absent, regional epithelialization appeared, the cytogram was of the regenerative type. In the comparison group, contamination before treatment was 8,1±0,17 Lg CFU/g (p<0.05), on the 5th and 10th day the indices were significantly higher than main group– 6,2±0.18 Lg CFU/g (p<0,01) and 3,8±0.19 Lg CFU/g (p<0,01), respectively and the cytograms were still of inflammatory type. The proposed comprehensive method of VAC-therapy provides an effective antibacterial, anti-inflammatory effect, promotes better regeneration and significantly improves the wound healing.