Neurodegerative diseases NDDs, such as Alzheimer’s and Parkinson’s diseases influence the brain tissues and cells that led to perpetual damage, reduce the quality of life and life-threating, although considerable advances in conception the mechanisms of these diseases and their pathogenesis. Thus, developing effective treatments against neurodegenerative disorders still challenging. In this regard, imidazole derivatives have showed a potential to be multi target-directed agent that has multifunctional biological activities to restrict NDDs. Imidazole is a heterocyclic compound with structural features enable different biological activities based on the substituted. This review discusses the roles of different imidazole derivatives to be candidate as a treatment of NDDs. Modification of imidazole moiety has been recognized so as favorable multi target to treat NDDs. Herein, we suggest that imidazole can be modified properly to increase its potential to be applied for pre-clinical and clinical studying of NDDs treatment.

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A NOVEL series of 1,4-benzoxazinone derivatives were synthesized and characterized using FT-IR , 1H-NMR, 13C-NMR and Mass spectroscopy. These compounds were in vitro screened against several bacterial species gram positive and gram negative as well as Candida albicans and found exhibiting moderate to potent activity. The antioxidant study was confirmed for the synthesized derivatives against 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical. Docking study for the potent compound 8 against glucosamine-6-phosphate synthase , the target enzyme for the antimicrobial agents was explored to explain the interactions of the discovered hits with in the amino acid residues of the enzyme active side. The docking parameters enhanced the activity of new compound as promising antimicrobial agents.