The increasing clinical importance of drug-resistant fungal and bacterial pathogens has stimulated microbiological research into and development of new antimicrobial agents. Hence, in this study, we synthesized novel series of 2-(pyridin-3-yl)-1H-benzo[d]imidazoles and 2-(pyridin-3-yl)-3H-imidazo[4,5-b]pyridine derivatives. The structures of the compounds were confirmed by spectral and CHN analysis. The compounds were examined for in-vitro antimicrobial activity against Gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis), Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa), and the fungus Candida albicans.

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1,4-Dihydropyridines are excellent precursors of various pharmacologically important molecules which possess calcium channel blocking activity. The synthesis of various 1,4-dihydro pyridines and their importance is reviewed for the first time to our knowledge.

Keywords:Dimethyl phthalate, one-pot synthesis, green synthesis and water; 2H-indazolo[2,1-b]phthalazine-trione derivatives Water mediated one-pot, four-component synthesis of substituted 2H-indazolo[2,1-b]phthalazine-triones from dimethyl phthalate, hydrazine, dimedone and aromatic aldehydes have been reported in the presence of p-toluenesulfonic acid (PTSA) as catalyst at 100 °C for 1.5-2.0 h. This methodology offers several advantages such as good yields, short reaction time, simple procedure, mild condition and environmentally begins. * Corresponding Authors

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