There is little information on the profile of children with ambiguous genitalia in India. Presented here is an analysis of patients with ambiguous genitalia registered in a general endocrine clinic during the last 2 decades. Seventy-four patients (age 4 months to 36 years) were registered during this period. Fifty-two were more than 5 years old at the time of registration. Thirty-five were reared as females, 29 as males; nine children (4 months to 1 year old) were brought for sex assignment, and one (with epispadias) was brought for correction of urinary incontinence. Investigations revealed 28 patients with congenital adrenal hyperplasia, 14 dysgenetic male pseudohermaphroditism, ten true hermaphroditism, six partial androgen insensitivity, four castration and one epispadias. There were eight patients with perineal hypospadias with normal Leydig cell reserve (normal LH, FSH and testosterone response to LHRH). Sex of rearing and gender identity were concordant in all except the patients with perineal hypospadias with normal Leydig cell response. These observations support the theory that prenatal androgen exposure masculinizes the brain.

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BACKGROUNDVD is considered as Abnormal Vaginal Discharge (AVD) when it is either a hypervaginal secretion not associated with menstruation or offensive/malodorous discharge or yellowish discharge. The various causes of AVD can be broadly divided into physiological and pathological.

BACKGROUNDVaginal discharge (VD) is one of the most common clinical complaints among women of reproductive age in many parts of the world. 1/2 It may present with varied symptoms & and has many etiologies.