High tibial osteotomy can be effective for periods longer than 15 years; however, results do deteriorate over time. Age less than 50 years, normal BMI, and ACL deficiency were independent factors associated with improved long-term survival of HTO.

Good results are maintained at 15 years after surgery with respect to ligamentous stability, subjective outcomes, and range of motion. Kneeling pain remains a significant problem. Concern remains regarding the incidence of further anterior cruciate ligament injury and the increasing number of patients with radiographic and clinical signs of osteoarthritis despite surgical stabilization.

The expression pattern of platelet-derived growth factor (PDGF) and its receptor suggest a role in lens cell proliferation. PDGF is strongly expressed in the iris and ciliary body, situated opposite the proliferative cells of the lens epithelium which express the PDGF-alpha receptor. In this study, using lens epithelial explant cultures, we report that PDGF can induce a dose and time dependent increase in lens cell DNA synthesis. Culturing lens explants with both PDGF and FGF (a mitogen and differentiation factor for lens cells) resulted in responses greater than those induced by either growth factor alone. PDGF did not induce any changes typical of fibre differentiation; however, in combination with FGF it potentiated the fibre differentiating activity of FGF. Results obtained in this study support previous indications that PDGF has an important role in regulating lens cell proliferation. In addition, PDGF may have a role in potentiating FGF-induced lens fibre differentiation in vivo.

Trachoma is the most frequent cause of preventable blindness in the world. At the trichiasis/entropion stage, lid surgery is recommended, but many patients only use epilation, which does not prevent loss of vision. We developed a new treatment that should be more accessible than lid surgery and more effective than epilation: a sticking plaster that forces eyelashes back to their correct position. The first randomized controlled trial was conducted in Shanghai with 57 patients to compare the plaster method with epilation. After 3 months of follow‐up, with no attrition, 67% of those treated by the new method presented a good clinical status, vs none of those treated by epilation (P < 0.001). The new treatment was well tolerated and lid function remained normal. Although our results show overwhelming benefit of this new, simple treatment for trachoma at the trichiasis stage, more research is needed at the primary health care level and in other settings to determine the potential use of the new method on a large scale and by nonspecialists. RésuméLa trachome est la première cause de cécitéévitable dans le monde, avec 146 millions de personnes atteintes. Au stade trichiasis/entropion, le traitement chirurgical est recommandé, mais pour beaucoup de patients l'épilation des cils reste le seul traitement, insuffisant pour éviter la perte de la vue. Nous avons développé une nouvelle méthode de traitement, qui se veut plus accessible que la chirurgie et plus efficace que l'épilation: la contention des cils par un sparadrap double‐face. Le premier essai clinique randomisé est présenté, comparant le nouveau traitement à l'épilation, conduit à Shanghai en milieu universitaire avec 57 patients. Après trois mois de suivi, sans perte, 67% des patients traités par contention avaient un status oculaire clinique bon, contre 0% dans le groupe épilation (P < 0.001). Le traitement par contention est bien toléré et il permet de battre des cils normalement. Nos résultats démontrent donc l'efficacité de ce nouveau traitement du trachome au stade trichiasis, d'usage simple et bon marché. Des essais dans des centres de soins primaires et dans d'autres cultures sont nécessaires pour préciser l'usage possible du nouveau traitement par des non‐spécialistes et sur une large échelle.

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