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A correlation between the distribution of charged side groups in the globule of Bacillus intermedius 7P ribonuclease (binase) and the process of heat denaturation was studied at different pH values in order to estimate a relation between charge distribution in globular proteins and the character of cooperative thermodynamic transitions. As was shown by comparing the results of scanning microcalorimetric analysis of heat denaturation with the three-dimensional structure of binase, at optimal pH the molecule exists as a single cooperative system stabilized by hydrogen bonds, Van der Waals' contacts, and electrostatic interactions like salt bridges. At pH lower than 4.0 (below the physiological optimum) the cooperativity type of the system was found to change due to a reversible cooperative transition in the ternary structure of the protein globule. It has been concluded that the molecular architecture and the arrangement of atoms do not change considerably in different environments; thus the thermodynamic properties of the globule vary due to the alteration of charge distribution and the consequent changes in the size and number of cooperative regions of the globule. Thus, structural and energetic domains may be non-coincident in proteins.

Th is text looks at the early Communist intellectual movement in Slovakia (in an area that, for part of the time under discussion, was affi liated with the the Hungarian Soviet Republic) organized around the journal Kassai Munkás (Th e Košice Worker). By placing this movement in the context of the development of Western Marxism and the incipient Marxist aesthetics of György Lukács, who was among those who published in the journal, the paper characterizes the movement's contribution to discussions of the meaning of proletarian culture, which elaborated on the concept of social culture developed by Lukács in his radical period.

Th is text looks at the early Communist intellectual movement in Slovakia (in an area that, for part of the time under discussion, was affi liated with the the Hungarian Soviet Republic) organized around the journal Kassai Munkás (Th e Košice Worker). By placing this movement in the context of the development of Western Marxism and the incipient Marxist aesthetics of György Lukács, who was among those who published in the journal, the paper characterizes the movement's contribution to discussions of the meaning of proletarian culture, which elaborated on the concept of social culture developed by Lukács in his radical period.

No abstract