The prototype experimental example of "spontaneous" pattern formation in an unstirred chemical medium is the oscillatory Belousov-Zhabotinsky (BZ) reaction: target patterns of outward-moving concentric rings are readily observed when the reaction is run in a thin layer in a Petri dish. In many experimental runs, new target centers appeared to form closer to pre-existing target centers than expected in a randomized model. Here we describe a simple direct test for the presence of temporal order in the spatiotemporal dynamics of target nucleation, and apply this test to detect significant temporal order in target formation in the ferroin-catalyzed BZ reaction. We also describe how mixing heterogeneity can generate temporal order, even in the absence of heterogeneous physical nucleating centers.

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A689costs and Life-years gained (LYG) offset based on incremental survival rate of compared therapies. Probabilistic Multivariable sensibility analysis was completed with 5,000 simulated patients. Results: Survival rate and confidence interval obtained from model was 0.63 (0.60, 0.66) for paricalcitol and 0.46 (0.44, 0.48) for PTX. Average survival of both therapies resulted in an incremental 0.61 LYG for paricalcitol patients (+18%). Average five years treatment cost for Paricalcitol patients was $10,024.25, while PTX was US$5,369.74(-46%) resulting in an ICER of US$7,619.94 per LYG, which is 28.2% below Mexican Gross Domestic Product (GDP) per capita. Probabilistic analysis shown: 90.1% of patient treated had a cost-effective outcome and 7.2% of cases had a dominant outcome. ConClusions: According to results obtained and using a threshold of US$29,306.29 (3 x GDP per capita), Paricalcitol is a highly cost-effective treatment option compared to PTX when treating patients with SHPT at IMSS. PDB10 Cost-EffECtivEnEss of fixED-DosE ComBination (fDC) of vilDagliPtin/ mEtformin for thE trEatmEnt of DiaBEtEs mEllitus tyPE 2 in mExiCo

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