Four new polyketide derivatives, Trichodermatides A-D (1-4) were isolated from the marine-derived fungus Trichoderma reesei. Trichodermatide A (1) is an unprecedented example of a polyketide with a ketal-containing pentacyclic skeleton. The chemical structures and absolute configurations of compounds 1-4 were elucidated by extensive spectroscopic methods, especially 2D NMR and CD spectral analysis, and supported by their proposed biosynthesis pathway. The cytotoxicity of 1-4 was evaluated against A375-S2 human melanoma cell line.

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Other bioactive products U 1300Trichodermatides A-D, Novel Polyketides from the Marine-Derived Fungus Trichoderma reesei. -[with weak cytotoxicity against A 375-S2 melanoma cell line]. -(SUN, Y.; TIAN, L.; HUANG, J.; MA, H.-Y.; ZHENG, Z.; LV, A.--.; YASUKAWA, K.; PEI*, Y.-H.; Org.