The article presents the results of a study of plasma donors as an agent of information impact in a pandemic situation. The key problem is the need to socially advance anti-pandemic measures in the face of poorly managed social responses to the fight against a pandemic. The analysis of the research results demonstrates a sufficiently high level of rational critical thinking of plasma donors in relation to being informed about the pandemic and combating it. It is concluded that the fixed position of plasma donors in the information space creates a stable foundation for the effective inclusion of this group in the processes of information support of anti-pandemic measures.