Biogas upgrading to produce biomethane is emerging as one of the distinguished solutions to the current energy crisis and environmental challenges. Biogas upgraded biomethane is gaining importance as fuel source and can be injected into the natural gas grid. This necessitates the need for energy efficient upgrading technologies. Among the upgrading technologies available, amine scrubbing is considered as a promising method due to low operating pressure, high methane recovery rates and low power consumptions. This paper presents an evaluation of amine scrubbing for biogas upgrading using aqueous solution formulations of piperazine activated methyl diethanolamine (MDEA) in Unisim software. The objective of this study was to coin optimal operating conditions for biomethane production from raw biogas by considering the technical, environmental and economic aspects. The performance of the process was evaluated in terms of mole fraction of methane in biomethane, recovery rate of methane and energy consumption by varying the operating parameters like absorber operating pressure, number of stages of the absorber, flowrate of the solvent and piperazine concentration in aqueous MDEA.