Nowadays, there is an increasing tendency towards the number of patients addicted to opioid-related drugs, which are relatively freely available in pharmacies due to due to violations of the prescription regulations. Few analgesics have a competitive advantage compared to opioid analgesics, but their prolong taking can result in marked metabolic changes leading to the disability and mortality among opioid-addicted patients. This situation requires in-depth study of pathogenetic mechanisms underlying the development of multiple organ comorbidities. Our study presents the analysis of data in special literature on structural remodelling of body tissues over the period of psychoactive substance intake, and in particular opioid analgesics. It has been found out that that there is a direct correlation between the changes in organs and tissues and the duration of exposure and the dosage of opioid analgesics. According to the literature, the first changes occurred in the initial stages of experimental research. Prolonged exposure to opioid analgesics led to serious dystrophic changes, which then turned into destructive ones and manifested by cell destruction. Therefore, the problem of the impact produced by opioid substances on the morphological remodelling of organs and systems is of great medical and social irrelevance. Prolonged use of opioids contributes to the development of a chronic endogenous intoxication that results in chronic multiple organ failure. This severe condition results from morphological alterations, which play an important role in the pathogenesis of a number of diseases. A lot of issues concerning to organ remodelling due to long-term use of narcotic analgesics remain are still unclear. Therefore, studying the structure of organs under the impact of opioids is essential for medical researchers and clinicians in terms of the elaboration of the preventive measure and effective approaches in treating prolonged opioid addiction.